Famous dead meat-moguls.

Jim Cantalupo, Chairman and CEO of McDonald's, died of a heart attack APR 19, 2004, in Orlando, Florida, site of the McDonald’s Worldwide Owner/Operator Convention.

And two weeks later, the new CEO, Charlie Bell, underwent successful colorectal cancer surgery.

Atkins diet author home after cardiac arrest
April 25, 2002 Posted: 5:13 PM EDT (2113 GMT)

NEW YORK (CNN) -- Nutrition expert and author Dr. Robert Atkins, creator of the high-protein/low-carbohydrate "Atkins Diet," was released Wednesday from hospital care and is resting well after his heart stopped, a condition called cardiac arrest. Atkins was waiting for breakfast at a restaurant near his office last Thursday in Manhattan when he went into cardiac arrest. He was quickly revived by an associate and taken to the New York Weill Cornell Medical Center. The episode was caused by cardiomyopathy, a condition in which the heart's ability to pump blood is weakened because of enlargement, thickening or stiffening of the heart muscle. In Atkins' case, cardiomyopathy was caused by an infection that spread to his heart muscle. "I have had cardiomyopathy, which is a non-coronary condition and is in no way related to diet," Atkins said in a statement. A statement by The Atkins Companies also said the hot weather in New York may have been a factor in the cardiac arrest. Temperatures last week in New York were in the 90s. "We have been treating this condition, cardiomyopathy, for almost two years," said Patrick Fratellone, Atkins' personal physician and cardiologist. "Clearly, his own nutritional protocols have left him, at the age of 71, with an extraordinarily healthy cardiovascular system." Atkins told CNN, "I want the public to know the truth, not every condition affecting the heart comes from a blockage." He said "a controlled carbohydrate lifestyle really prevents risk factors for heart disease." Doctors have checked for blockages, Atkins said, "and I don't have any." Dr. Clyde Yancy, a cardiologist at the University of Texas Southwestern Medical Center in Dallas and a member of the American Heart Association's national board of directors, said: "Despite the obvious irony, I believe there is a total disconnect between the cardiac arrest and the health approach he (Atkins) popularizes." Atkins' doctors have advised him to curtail his travel plans for the next 30 days as a precaution, but Atkins hopes to return to his work within the next week or so. Paul Wolff, chief executive officer of The Atkins Companies, said: "Up until today, this has been a personal and private family matter for Atkins. It is unfortunate for the family that this has not remained so."

Obituary for John M. Eisenberg, America's Top Doc
March 15, 2002

  John M. Eisenberg, MD, MBA, died at his home in Potomac, Maryland, at the young age of 55 on March 10, 2002, following a 14-month battle against a high-grade malignant glioma. A native of Atlanta, Georgia, John spent his boyhood in Memphis, Tennessee, and took his undergraduate degree at Princeton in 1968. His medical degree was from Washington University and his internal medicine training, as well as his MBA, were received at the University of Pennsylvania.

  So what's a glioma?  A neuroectodermal tumour of neuroglial origin.
  What causes them?

Int J Cancer 1993 Feb 20;53(4):561-5
Dietary carcinogens and the risk for glioma and meningioma in Germany.
Boeing H, Schlehofer B, Blettner M, Wahrendorf J. German Cancer Research Center, Division of Epidemiology, Heidelberg.

  A population-based case-control study was performed in South-West Germany in 1987/88 with 115 histological confirmed glioma and 81 meningioma cases and 418 randomly selected controls. ... The intake of processed meat was significantly associated with an increased risk of glioma. ... Among single meat products, a significantly higher risk of glioma was found for cooked ham, processed pork meat and fried bacon. For the consumption of 3 N-nitrosamines, assessed from the intake of processed meat and cheese, significant positive relations to glioma risk were found. ... The risk for occurrence of glioma was significantly increased for those using vegetable fat frequently for deep frying, as compared with non-users.

PMID: 8436429

Am J Epidemiol 1997 Nov 15;146(10):832-41
Nutritional factors in the etiology of brain tumors: potential role of nitrosamines, fat, and cholesterol.
Kaplan S, Novikov I, Modan B. Department of Clinical Epidemiology, Chaim Sheba Medical Center, Tel Hashomer, Israel.

  ... A significant positive association for both types of brain tumors was found with high protein intake ...

PMID: 9384204

Cancer Causes Control 1997 Jan;8(1):13-24
Dietary and tobacco risk factors for adult onset glioma in the San Francisco Bay Area (California, USA)
Lee M, Wrensch M, Miike R. Department of Epidemiology and Biostatistics, University of California, San Francisco 94143-0560, USA.

  ... Adjusted for age, family income, and education, for both men and women, cases had higher mean weekly consumption of cured meats and other cured foods, lower consumption of high vitamin A and C fruits and vegetables, and higher average intakes of beer and other alcohol than controls. Men with brain cancer were twice as likely as control men to report high consumption of cured foods and low consumption of foods rich in vitamin C (odds ratio [OR] = 2.0, 95 percent confidence interval [CI] = 1.2-3.5). ... Similarly, men with brain cancer were twice as likely as controls to have high nitrite and low vitamin C consumption. ...

PMID: 9051318

Cancer Causes Control 1997 Jan;8(1):5-12
Dietary and other lifestyle factors of women with brain gliomas in Los Angeles County (California, USA)
Blowers L, Preston-Martin S, Mack WJ. Department of Preventive Medicine, School of Medicine, University of Southern California, Los Angeles, USA.

  ... Risk increased with increasing consumption of cured meats, most notably of bacon (odds ratio [OR] for the third tertile of intake = 6.6, 95 percent confidence interval [CI] = 1.9-22.5, P trend < 0.001). Risk was reduced with increasing intake of vegetables such as bell peppers (OR for third tertile = 0.2, CI = 0.1-0.7, P trend < 0.01). ... Despite the limitations of data on usual adult diet, it appears that dietary sources of nitroso compounds may be important in the development of gliomas.

PMID: 9051317

Dave Thomas, the folksy founder of Wendy's Old-Fashioned Hamburgers, which has sales of more than $8 billion a year, who parlayed his taste for good food and friendly service and an innate knack for talking to people from their television sets into one of the world's most successful fast-food chains, died Tuesday (JAN 8, 2002) at his Fort Lauderdale, Fla., home of liver cancer. He was 69.  Thomas had been undergoing kidney dialysis since early last year and had a quadruple heart bypass five years ago after suffering a heart attack.  It was in Fort Wayne, Indiana, that Thomas met another mentor, Col.Harland Sanders, who stopped by to promote his Kentucky Fried Chicken franchises. Dave's boss acquired four KFC franchises in Columbus, Ohio, and, when they did poorly, sent Thomas to turn them around in exchange for 45% ownership. Thomas succeeded, and in 1968 sold his interest back to KFC for $1 million in stock. A year later, he established his own company, opening the first Wendy's in Columbus on Nov. 15, 1969.
Col Harland Sanders, founder of Kentucky Fried Chicken, died of leukemia in 1980 at the age of 90.
Ray A. Kroc, the builder of the McDonald's hamburger empire, who helped change American business and eating habits by deftly orchestrating the purveying of billions of small beef patties, died JAN 15, 1984 of a heart ailment at 81.
Dr. Jean Mayer, establishment "nutritional researcher" and advocate of meat-eating dies of a meat-induced disease: "heart attack".


  A memorial service to celebrate the life of Dr. Jean Mayer, former president and chancellor of Tufts University, will be held at 1:30 p.m. Feb. 1 in the Cohen Auditorium on the Tufts University campus. Dr. Mayer, who had led Tufts as president for 16 years before being made the university's first chancellor last fall, died Jan. 1 of a heart attack while on vacation in Florida. He was 72.

Jean Mayer's death on New Year's Day brought to an untimely close his extraordinary work in behalf of Tufts University. He had moved from the Tufts presidency to become the university's first chancellor less than two months earlier. As president he transformed Tufts, founding several graduate schools and dramatically enlarging its range of programs. He moved Tufts into new realms: veterinary medicine, biomedical science, nutritional studies and research into the process of aging.

SOURCE: By Dianne Dumanoski, Globe Staff
   Friends and colleagues who mourned the death of Tufts University Chancellor Jean Mayer yesterday remembered him first and foremost as a dauntless and indefatigable visionary with a mind and a conscience of truly global scope. During his 16 years as its leader, they say, he not only transformed Tufts into an institution of international stature, but acted in countless ways to realize an activist vision of the university as a leading agent for social change at home and in the larger world.

SOURCE: By Judy Foreman, Globe Staff
  Jean Mayer, visionary, nutritionist, recipient of three Croix de Guerre and nearly a dozen other French military honors, president of Tufts University and, most recently, its first chancellor, died yesterday of a heart attack. He was 72. Mayer died about 5:45 a.m. in Florida en route to the airport in Sarasota to return to Boston, said his family, speaking through Tufts officials.

     He also was Professor of Nutrition, and Lecturer on the History of Public Health at Harvard, and and prolific writer on food and nutrition, member of the Presidential Commission on World Hunger (1978-1980), and the President of of Tufts University (1976-1992), during which Tufts was transformed from a small liberal arts college into a research university with an international reputation.  He testified before congressional committees as an expert on hunger and nutrition and developed the first Graduate School of Nutrition in the United States at Tufts, the School of Veterinary Medicine, first of its kind in New England, the Tufts United States Department of Agriculture Nutrition Research Center on Aging in Boston (one of six "nutrition research centers" in the US supported by the USDA, thus the economic ties to the agricultural industry are revealed), and the Center for Environmental Management, and was involved in the Presidential Commission on World Hunger.  He wrote "Food for thought." a biweekly column syndicated in approximately 150 newspapers in the United States (1979-92).

  Apparently, in spite of all his research and academic expertise, he forgot he was a frugivorous ape and ate himself to death, as do all who mindlessly follow the local cultural diet.

Jeffrey Isner, MD 1947-2001

The international cardiology community mourns the untimely death of Dr. Jeffrey Isner. Jeffrey will be missed as a pioneer of gene therapy in the prime of his career, as a devoted family man, and as a caring loyal friend. He was a consummate professional whose vision extended far beyond his early work in interventional cardiology. In the past decade, his basic and clinical laboratory produced impressive exciting data concerning the application of vascular endothelial growth factor (VEGF) for the treatment of myocardial ischemia as well as lower extremity claudication.[1]

November 3, 2001 Dr. Jeffrey M. Isner, a Boston cardiologist who pioneered the use of gene therapy to treat people with heart disease, died unexpectedly early Wednesday morning of a heart attack. He was 53... Isner's program fell under scrutiny from the Food and Drug Administration following the 1999 death of a University of Pennsylvania patient in a gene therapy trial. In the ensuing FDA investigation of all gene therapy centers, his clinical trials were shut down in February 2000. FDA officials said that he had failed to report the death of one patient to the hospital's safety review board and had endangered the lives of other patients by improperly enrolling them in the trials.[2]

Second Death in Gene Therapy Comes to Light
     Source: The New York Times--May 4, 2000
Investigators for the Food and Drug Administration say that researchers at St. Elizabeth's Medical Center in Boston failed to report the death of a patient in gene therapy, and may have allowed the growth of a known cancer in another patient. The experiments were subsequently halted. The news comes as scientists, hospitals, and companies fall under close scrutiny in the wake of the first gene therapy death of Jesse Gelsinger. Despite the fact that such issues current abound, inspectors for the F.D.A. have stated that they found several violations of ethical and safety requirements, most conspicuous of which was the lack of reporting of the death. Inspectors have stated that there were also problems with the recruitment of the participants for the study, in that necessary tests were not performed, and those ineligible for the study may have been included. It appears that Dr. Jeffrey M. Isner, the chief researcher of the project, is the founder of the company leading the protocols, and is also a major stockholder in it.[3]

Dr. Jeffrey Isner of St. Elizabeth's Medical Center in Boston, MA discusses his ground-breaking work and recent results in gene therapy and angiogenesis in both the peripheral (leg) vessels and the coronary arteries[4]

"It was a very logical approach," says Dr. Jeffrey Isner, Chief of Vascular Medicine and Cardiovascular Research at St. Elizabeth's Medical Center in Boston as well as Professor of Medicine at Tufts University School of Medicine. "But in most cases the strategy failed,...[5]

Ethical Problems for Gene Therapy
May 3 (CBS)
  News tonight about a gene-research controversy that CBS News has been reporting in-depth: the risks to patients who receive experimental gene therapies designed to treat diseases. Medical Correspondent Elizabeth Kaledin has been digging into the latest revelations. In the field of gene therapy Dr. Jeffrey Isner is a leading force. His experiments manipulating genes to reverse heart disease are on the cutting edge and his results have been promising. But even he admits it's risky business. Isner says "there are certain risks we're taking as doctors and investigators here, but the real risks are being taken by the patients." Now, after investigating Isner's research and shutting it down, the FDA has determined he was taking a few too many risks, knowingly enrolling a patient in his study who had cancer. This revelation has prompted a warning letter from the FDA that says that Isner "did not fulfill your obligations as a clinical investigator." The letter also accuses him of "a serious lack of study oversight." In Isner's experiments, genes that promote blood vessel growth are injected into patients' failing hearts--to improve blood flow. But in a patient with cancer, the same genes that create blood vessel growth can also cause tumor growth. Gene therapy ethicists are at a loss to explain how anyone with cancer would have been in Isner's study. "If someone is supposed to be excluded because of reasons of safety and they end up being included...that's a terrible ethical violation," says Dr. Ruth Macklin, a gene therapy ethicist. Compounding Isner's ethical dilemma is that he is invested in the company backing his research--Vascular genetics. Isner will not comment. The FDA has given him 15 days to respond to it's [sic] warning. In the meantime, what was promising research has been derailed--both by an apparent disregard for patient safety and by a growing lack of public confidence in gene therapy.[6]

NOTE: if research cardiologists die of heart disease at a very early age, then of what value is the Medical System? ljf



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